I tried to create a SQL Server Lob target from within Visual Studio and got this error.
The URL I was trying to use was http://localhost:8080/BAService/ManagementService.svc/. Some have said to use https://localhost:8080/BAService/ManagementService.svc/ but this caused more errors.
Eventually I discovered that I had Imported the BizTalk Service self-signed certificate to the Trusted Root Certificate Authority on my user account instead of the local computer. Dohhh.!
The moral of the story is to use the developer prompt “
Certutil -addstore root c:\wabsselfsigned.cer” as described here.